RapamycinFungusV1, Main, Exploration, bibRecord, 001757

Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.

Identifieur interne : 001757 ( Main/Exploration ); précédent : 001756; suivant : 001758

Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.

Auteurs : Melanie L. Oakes [États-Unis] ; Imran Siddiqi ; Sarah L. French ; Loan Vu ; Manabu Sato ; John P. Aris ; Ann L. Beyer ; Masayasu Nomura

Source :

Molecular and cellular biology [ 0270-7306 ] ; 2006.

RBID : pubmed:16648483

Descripteurs français

English descriptors

KwdEn :
- Cell Nucleolus (ultrastructure), Chromatin (ultrastructure), Gene Deletion (MeSH), Gene Expression Regulation, Fungal (MeSH), Genes, Fungal (MeSH), Genes, rRNA (genetics), Genetic Variation (MeSH), Histone Deacetylases (genetics), Histone Deacetylases (metabolism), Histone Deacetylases (ultrastructure), Microscopy, Fluorescence (MeSH), Plasmids (genetics), RNA Polymerase II (metabolism), RNA, Ribosomal (biosynthesis), RNA, Ribosomal (genetics), RNA, Ribosomal (ultrastructure), Repressor Proteins (genetics), Repressor Proteins (metabolism), Repressor Proteins (ultrastructure), Saccharomyces cerevisiae (enzymology), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae Proteins (MeSH), Transcription Factors (genetics), Transcription Factors (metabolism), Transcription Factors (ultrastructure), Transcription, Genetic (MeSH).
MESH :
- chemical , biosynthesis : RNA, Ribosomal.
- chemical , genetics : Histone Deacetylases, RNA, Ribosomal, Repressor Proteins, Transcription Factors.
- chemical , metabolism : Histone Deacetylases, RNA Polymerase II, Repressor Proteins, Transcription Factors.
- chemical , ultrastructure : Chromatin, Histone Deacetylases, RNA, Ribosomal, Repressor Proteins, Transcription Factors.
- enzymology : Saccharomyces cerevisiae.
- genetics : Genes, rRNA, Plasmids, Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- ultrastructure : Cell Nucleolus.
- Gene Deletion, Gene Expression Regulation, Fungal, Genes, Fungal, Genetic Variation, Microscopy, Fluorescence, Saccharomyces cerevisiae Proteins, Transcription, Genetic.

Abstract

The 35S rRNA genes at the RDN1 locus in Saccharomyces cerevisiae can be transcribed by RNA polymerase (Pol) II in addition to Pol I, but Pol II transcription is usually silenced. The deletion of RRN9 encoding an essential subunit of the Pol I transcription factor, upstream activation factor, is known to abolish Pol I transcription and derepress Pol II transcription of rRNA genes, giving rise to polymerase switched (PSW) variants. We found that deletion of histone deacetylase gene RPD3 inhibits the appearance of PSW variants in rrn9 deletion mutants. This inhibition can be explained by the observed specific inhibition of Pol II transcription of rRNA genes by the rpd3Delta mutation. We propose that Rpd3 plays a role in the maintenance of an rRNA gene chromatin structure(s) that allows Pol II transcription of rRNA genes, which may explain the apparently paradoxical previous observation that rpd3 mutations increase, rather than decrease, silencing of reporter Pol II genes inserted in rRNA genes. We have additionally demonstrated that Rpd3 is not required for inhibition of Pol I transcription by rapamycin, supporting the model that Tor-dependent repression of the active form of rRNA genes during entry into stationary phase is Rpd3 independent.

DOI: 10.1128/MCB.26.10.3889-3901.2006
PubMed: 16648483
PubMed Central: PMC1489006

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001792
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Le document en format XML

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<term>Chromatin (ultrastructure)</term>
<term>Gene Deletion (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Genes, Fungal (MeSH)</term>
<term>Genes, rRNA (genetics)</term>
<term>Genetic Variation (MeSH)</term>
<term>Histone Deacetylases (genetics)</term>
<term>Histone Deacetylases (metabolism)</term>
<term>Histone Deacetylases (ultrastructure)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Plasmids (genetics)</term>
<term>RNA Polymerase II (metabolism)</term>
<term>RNA, Ribosomal (biosynthesis)</term>
<term>RNA, Ribosomal (genetics)</term>
<term>RNA, Ribosomal (ultrastructure)</term>
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<term>Repressor Proteins (metabolism)</term>
<term>Repressor Proteins (ultrastructure)</term>
<term>Saccharomyces cerevisiae (enzymology)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (growth & development)</term>
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<term>Transcription Factors (metabolism)</term>
<term>Transcription Factors (ultrastructure)</term>
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<term>ARN ribosomique (génétique)</term>
<term>ARN ribosomique (ultrastructure)</term>
<term>Chromatine (ultrastructure)</term>
<term>Délétion de gène (MeSH)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Facteurs de transcription (ultrastructure)</term>
<term>Gènes d'ARN ribosomique (génétique)</term>
<term>Gènes fongiques (MeSH)</term>
<term>Histone deacetylases (génétique)</term>
<term>Histone deacetylases (métabolisme)</term>
<term>Histone deacetylases (ultrastructure)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Nucléole (ultrastructure)</term>
<term>Plasmides (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (MeSH)</term>
<term>Protéines de répression (génétique)</term>
<term>Protéines de répression (métabolisme)</term>
<term>Protéines de répression (ultrastructure)</term>
<term>RNA polymerase II (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (croissance et développement)</term>
<term>Saccharomyces cerevisiae (enzymologie)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Transcription génétique (MeSH)</term>
<term>Variation génétique (MeSH)</term>
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<term>Repressor Proteins</term>
<term>Transcription Factors</term>
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<term>Repressor Proteins</term>
<term>Transcription Factors</term>
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<term>RNA, Ribosomal</term>
<term>Repressor Proteins</term>
<term>Transcription Factors</term>
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<term>Facteurs de transcription</term>
<term>Gènes d'ARN ribosomique</term>
<term>Histone deacetylases</term>
<term>Plasmides</term>
<term>Protéines de répression</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Histone deacetylases</term>
<term>Protéines de répression</term>
<term>RNA polymerase II</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cell Nucleolus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Deletion</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Genes, Fungal</term>
<term>Genetic Variation</term>
<term>Microscopy, Fluorescence</term>
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<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines de répression</term>
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<front><div type="abstract" xml:lang="en">The 35S rRNA genes at the RDN1 locus in Saccharomyces cerevisiae can be transcribed by RNA polymerase (Pol) II in addition to Pol I, but Pol II transcription is usually silenced. The deletion of RRN9 encoding an essential subunit of the Pol I transcription factor, upstream activation factor, is known to abolish Pol I transcription and derepress Pol II transcription of rRNA genes, giving rise to polymerase switched (PSW) variants. We found that deletion of histone deacetylase gene RPD3 inhibits the appearance of PSW variants in rrn9 deletion mutants. This inhibition can be explained by the observed specific inhibition of Pol II transcription of rRNA genes by the rpd3Delta mutation. We propose that Rpd3 plays a role in the maintenance of an rRNA gene chromatin structure(s) that allows Pol II transcription of rRNA genes, which may explain the apparently paradoxical previous observation that rpd3 mutations increase, rather than decrease, silencing of reporter Pol II genes inserted in rRNA genes. We have additionally demonstrated that Rpd3 is not required for inhibition of Pol I transcription by rapamycin, supporting the model that Tor-dependent repression of the active form of rRNA genes during entry into stationary phase is Rpd3 independent.</div>
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<Abstract><AbstractText>The 35S rRNA genes at the RDN1 locus in Saccharomyces cerevisiae can be transcribed by RNA polymerase (Pol) II in addition to Pol I, but Pol II transcription is usually silenced. The deletion of RRN9 encoding an essential subunit of the Pol I transcription factor, upstream activation factor, is known to abolish Pol I transcription and derepress Pol II transcription of rRNA genes, giving rise to polymerase switched (PSW) variants. We found that deletion of histone deacetylase gene RPD3 inhibits the appearance of PSW variants in rrn9 deletion mutants. This inhibition can be explained by the observed specific inhibition of Pol II transcription of rRNA genes by the rpd3Delta mutation. We propose that Rpd3 plays a role in the maintenance of an rRNA gene chromatin structure(s) that allows Pol II transcription of rRNA genes, which may explain the apparently paradoxical previous observation that rpd3 mutations increase, rather than decrease, silencing of reporter Pol II genes inserted in rRNA genes. We have additionally demonstrated that Rpd3 is not required for inhibition of Pol I transcription by rapamycin, supporting the model that Tor-dependent repression of the active form of rRNA genes during entry into stationary phase is Rpd3 independent.</AbstractText>
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Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.

Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.

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